​​​​​​Ariel Fernandez​

AI Scientist - Physicist

​Selected publications by Ariel Fernández

• Ariel Fernández, Tobin R. Sosnick and Andrés Colubri: “Dynamics of hydrogen-bond desolvation in folding proteins”, Journal of Molecular Biology 321, 659-675 (2002).
  
• Ariel Fernández and Harold A. Scheraga: “Insufficiently dehydrated hydrogen bonds as determinants for protein interactions”, Proceedings of the National Academy of Sciences, USA 100, 113-118 (2003).
  
• Ariel Fernández and R. Stephen Berry: “Proteins with hydrogen-bond packing defects are highly interactive with lipid bilayers: Implications for amyloidogenesis”, Proceedings of the National Academy of Sciences, USA 100, 2391-2396 (2003).
  
• Ariel Fernández and Ridgway Scott: “Adherence of packing defects in soluble proteins”, Physical Review Letters 91, 018102, 4 pages (2003).
  
• Ariel Fernández, Kristina Rogale, L. Ridgway Scott and Harold A. Scheraga: “Inhibitor design by wrapping packing defects in HIV-1 proteins”. Proceedings of the National Academy of Sciences, USA 101, 11640-11645 (2004).
  
• Ariel Fernández and R. Stephen Berry: “Molecular dimension explored in evolution to promote proteomic complexity”. Proceedings of the National Academy of Sciences, USA 101, 13460-13465 (2004).
  
• Ariel Fernández: “Keeping Dry and Crossing Membranes”. Nature Biotechnology 22, 1081-1084 (2004).
  
• Ariel Fernández, et al.: “An anticancer C-kit kinase inhibitor is re-engineered to make it more active and less cardiotoxic”. Journal of Clinical Investigation 117, 4044-4054 (2007).
  
• Ariel Fernández and Alejandro Crespo: “Protein wrapping: a marker for association, aggregation and molecular targeted therapy”. Chemical Society Reviews (Royal Society of Chemistry, UK) 37, 2373-2382, Impact Factor 34.09 (2008).
  
• Jianping Chen, Han Liang and Ariel Fernández: “Protein structure protection commits gene expression patterns”. Genome Biology 9, R107 (2008).
  
• Ariel Fernández and Jianping Chen: “Human capacitance to dosage imbalance: Coping with inefficient selection”. Genome Research 19, 2185-2192 (2009).
  
• Ariel Fernández and Michael Lynch: “Nonadaptive origins of interactome complexity”. Nature 474, 502-505 (2011).
  
• Ariel Fernández: “Epistructural tension promotes protein associations”. Physical Review Letters 108, 188102 (2012).
  
• Ariel Fernández and L. Ridgway Scott: “Advanced modeling reconciles “counterintuitive” decisions in lead optimization”. Trends in Biotechnology, CELL Press 35, 490-497 (2017) 
  
• Ariel Fernández: “Forum: Making targeted therapy compatible with checkpoint immunotherapy”. Trends in Biotechnology (CELL Press) 35, 582-585 (2017) DOI: http://dx.doi.org/10.1016/j.tibtech.2017.02.008 (2017).
  
• Ariel Fernández: “Engineering Tumor Hypersusceptibility to Checkpoint Immunotherapy”. Trends in Cancer (CELL Press) 3, 675-677 (2017).